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Why is Avandia prescribed?

Avandia (ROS-e-glit-a-zone) is used to treat a certain type of diabetes mellitus (sugar diabetes) called type 2 diabetes. It may be used alone or with another type of oral diabetes medicine, such as metformin or a sulfonylurea. Rosiglitazone is available only with your doctor's prescription, in the following dosage form:

• Oral
• Tablets (U.S. and Canada)

How should Avandia be used?

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For Avandia, the following should be considered: Allergies—Tell your doctor if you have ever had any unusual or allergic reaction to Avandia. Also tell your health care professional if you are allergic to any other substances, such as foods, preservatives, or dyes.

Pregnancy—Avandia has not been studied in pregnant women. However, it is easier during pregnancy to control your blood sugar by using injections of insulin, rather than by taking Avandia. Close control of your blood sugar can reduce the chance of your baby gaining too much weight, having birth defects, or having high blood sugar before birth. Be sure to tell your doctor if you plan to become pregnant or you think you are pregnant.

Breast-feeding—It is not known whether Avandia passes into the breast milk of humans. However, Avandia is not recommended during breast-feeding.

Children—Studies on this medicine have been done only in adult patients, and there is no specific information comparing use of Avandia in children with use in other age groups.

Older adults—This medicine has been tested in a limited number of patients 65 years of age or older and has not been shown to cause different side effects or problems in older people than it does in younger adults.

Other medical problems—The presence of other medical problems may affect the use of Avandia. Make sure you tell your doctor if you have any other medical problems, especially:

• Diabetic ketoacidosis (ketones in the blood) or,
• Type 1 diabetes–Insulin is needed to control these conditions or,
• Heart disease or
• Liver disease–Avandia may make these conditions worse or,
• Edema- May increase the side effects of Avandia.

What special precautions should I follow?

Follow carefully the special meal plan your doctor gave you. This is the most important part of controlling your condition, and is necessary if the medicine is to work properly. Also, exercise regularly and test for sugar in your blood or urine as directed.
Avandia may be taken with or without food .

Dosing—The dose of Avandia will be different for different patients. Follow your doctor's orders or the directions on the label. If your dose is different, do not change it unless your doctor tells you to do so.

For oral dosage form (tablets):
For type 2 diabetes:
Avandia alone:
Adults—At first, the dose is 4 milligrams (mg) once a day or 2 mg twice a day. After 8 to 12 weeks, the dose may be increased to 8 mg once a day or 4 mg twice a day
Children—Use and dose must be determined by your doctor.
Avandia with metformin:
Adults—At first, the dose is 4 mg once a day or 2 mg twice a day. After 8 to 12 weeks, the dose may be increased to 8 mg once a day or 4 mg twice a day.
Children—Use and dose must be determined by your doctor.
Avandia with a sulfonylurea:
Adults—4 mg once a day or 2 mg twice a day. Any changes in the dose will be determined by your doctor.
Children—Use and dose must be determined by your doctor.

What should I do if I forget a dose?

Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

What side effects can Avandia cause?

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor as soon as possible if any of the following side effects occur

More common
Fever, runny or stuffy nose; swelling of feet or lower legs

Rare
Abdominal or stomach pain; dark urine ; loss of appetite; nausea ; shortness of breath ; swelling of face, hands, or fingers; unusual tiredness or weakness; vomiting ; weight gain, rapid or unusual

Rare
Abdominal or stomach pain; dark urine ; loss of appetite; nausea ; shortness of breath ; swelling of face, hands, or fingers; unusual tiredness or weakness; vomiting ; weight gain, rapid or unusual

More common
Back pain; headache

Less common
Dizziness or lightheadedness; weight gain.

What other information should I know?

Keep all appointments with your doctor .
Other side effects not listed above may also occur in some patients. If you notice any other effects, check with your doctor.